在被诊断患有慢性白病和白敏感化的个体中死亡率
Hailey TenHarmsel1, Ling Wang, Constantine Dumas
1From the Division of Occupational and Environmental Medicine, Department of Medicine, College of Human Medicine, Michigan State University, East Lansing, MI (H.T., L.W., K.D.R.); and Materion Brush, Inc, Elmore, OH (C.D.).
Journal of occupational and environmental medicine
|December 28, 2023
概括
慢性病 (CBD) 增加了呼吸道死亡风险,而敏化 (BeS) 则没有. 这项研究澄清了暴露个体的死亡原因.
科学领域:
- 职业健康 职业健康 职业健康
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 暴露于可以导致慢性病 (CBD) 和敏感化 (BeS).
- 了解这些条件下的死亡率模式对于公共卫生至关重要.
- 以前的研究表明死亡风险增加,但具体原因需要进一步调查.
研究的目的:
- 调查被诊断患有慢性病 (CBD) 或敏感性 (BeS) 的个体的死亡原因.
- 为了确定特定的死亡原因是否在与CBD和BeS的队列中升高.
- 评估暴露,疾病状况和死亡结果之间的关系.
主要方法:
- 一项队列研究对354名拥有CBD和290名拥有BS的个人进行.
- 对所有参与者来说,确定了生命状态和死亡原因.
- 标准化死亡率 (SMR) 是根据潜在的死亡原因计算的.
主要成果:
- 在216名已故个体中,153人患有CBD,63人患有BES.
- 在CBD组中,非恶性呼吸道死亡和其他死亡原因显著增加.
- 在BES组中,没有任何特定死亡原因显著增加,肺癌死亡率在任何一组中都没有升高.
结论:
- 患有CBD的个人表现出增加的整体死亡风险,主要是由于呼吸道死亡率升高,无论暴露时间如何.
- 单独的敏化 (BeS) 与增加的呼吸道死亡率没有关联.
- 该研究发现,在研究的队列中,肺癌死亡率的风险没有增加.
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