2011-2021年间应用的皮下过敏原免疫治疗引起的不良反应的特征:单个中心的经验
Gürgün Tuğçe Vural Solak1, Kurtuluş Aksu1, Yavuzalp Solak2
1Division of Immunology and Allergic Diseases, Ankara Atatürk Sanatoryum Training and Research Hospital, University of Health Sciences, Ankara, Türkiye.
Tuberkuloz ve toraks
|December 28, 2023
概括
皮下免疫疗法 (SCIT) 是一种安全的过敏治疗方法,大多数反应都是局部的. 虽然全身反应很罕见,但医生必须保持警,以防潜在的过敏反应风险.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 皮下免疫疗法 (SCIT) 是对过敏疾病的常见治疗方法.
- 了解不良反应的发生率和特征对于患者安全至关重要.
- 之前的研究在报告SCIT相关不良事件方面存在差异.
研究的目的:
- 为了确定SCIT后局部,大型局部和全身反应的发生率.
- 在接受SCIT的患者中描述不良反应的特征.
- 评估SCIT在临床环境中的整体安全概况.
主要方法:
- 在10年的时间里,对6000名SCIT注射给163名患者进行了回顾性分析.
- 包括患有过敏犀牛结膜炎和毒液过敏的患者.
- 记录人口统计数据,诊断,过敏原敏感性,免疫治疗方案和不良反应.
主要成果:
- 在83名患者中观察到总共218次过敏反应,每次注射的总发病率为3.6%.
- 局部反应发生在43.1%的病例中,大局部反应发生在25.7%的病例中,全身反应发生在31.2%.
- 在SCIT期间患者出现任何不良反应的概率为53.9%.
结论:
- 一般来说,SCIT是对过敏的安全和耐受治疗方法.
- 虽然系统反应很少发生,但像过敏反应这样的严重事件的可能性需要医疗意识.
- 在开始SCIT之前,建议仔细评估好处和风险.
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