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在患有早期COPD非小细胞肺癌患者的表皮-介质细胞过渡变化
Wenying Lu1,2, Mathew Suji Eapen1, Ashutosh Hardikar3
1Respiratory Translational Research Group, School of Health Sciences, University of Tasmania, Newnham, TAS, Australia.
ERJ open research
|December 28, 2023
概括
表皮介质转换 (EMT) 在吸烟者和肺癌COPD患者的小气道中活跃. 这一过程有助于这些人呼吸道改造和癌症的发展.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 表皮-介质细胞过渡 (EMT) 与肺癌的发展有关,特别是在吸烟者和慢性阻塞性肺病 (COPD) 患者中.
- 这项研究调查了不同组非小细胞肺癌 (NSCLC) 患者的EMT,包括腺癌和状细胞癌.
- 该研究将吸烟者与COPD,小呼吸道疾病和正常肺功能与健康对照进行比较.
研究的目的:
- 为了说明EMT在非小细胞肺癌患者的小气道中的变化.
- 评估EMT生物标志物与吸烟者和COPD患者的呼吸道病理之间的关联.
- 为了比较腺癌和状细胞癌亚型之间的EMT标记物表达.
主要方法:
- 从46名受试者手术切除的小气道组织的分析.
- 气道壁厚度的测量和EMT生物标志物的免疫组织化学评估:E-cadherin,N-cadherin,S100A4,维门丁和EGFR.
- 使用Image-Pro Plus 7.0软件进行定量分析.
主要成果:
- 与对照组相比,在所有病理组中观察到气道壁厚度显著增加.
- 在病理组中发现了降低的E-cadherin和增加的N-cadherin,vimentin,S100A4和EGFR表达.
- 维门的表达在腺癌中更高,而S100A4在状细胞癌中更高;EGFR和N-cadherin明显高于其他标记物.
结论:
- 在吸烟者和被诊断为NSCLC的COPD患者的小气道中,EMT是一个活跃的过程.
- 在这些患者群体中,EMT有助于小气道重塑和肺癌的发展.
- 这些发现突显了EMT在吸烟和COPD相关的肺癌的病变发生中的作用.
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