在一般性性状态中超耐火性和死亡率的危险因素:一项为期10年的回顾性队列研究
Dongmei Wang1, Meirong Li2, Yue Pan1
1Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Therapeutic advances in neurological disorders
|December 28, 2023
概括
一般性性状态 (GCSE) 可以发展为超耐药性状态 (SRSE),自身免疫性脑炎和内感染是关键的危险因素. 中性粒细胞与淋巴细胞比率 (NLR) 预测死亡率,而血交换 (PE) 提高了GCSE患者的生存率.
科学领域:
- 神经学 神经学
- 临界护理医学 临界护理医学
- 神经临界护理是指神经临界护理.
背景情况:
- 一般性性状态 (GCSE) 是一种具有高死亡率的关键神经紧急情况,特别是在耐火性时.
- 尽管采取了积极的干预措施,但自20世纪90年代末以来,长期状态的死亡率一直停滞不前.
研究的目的:
- 在GCSE患者中确定与进展至超耐火状态 (SRSE) 相关的风险因素.
- 为了确定患有GCSE的患者死亡的风险因素.
主要方法:
- 进行了一项观察性回顾性队列研究,涉及106名入院于中国广州神经临界病房的GCSE患者 (2010年10月 - 2021年2月).
- 收集的数据包括社会人口统计信息,病因学,实验室结果,治疗和预后.
- 使用多变量逻辑回归分析来确定重要的风险因素.
主要成果:
- 近一半 (48%) 的GCSE患者进展到SRSE.
- 自免疫性脑炎和内感染被确定为SRSE进展的危险因素.
- 中性粒细胞与淋巴细胞的比率 (NLR) 在入院时预测了住院死亡率,而NLR在出院时预测了6个月死亡率.
- 血交换 (PE) 被发现是预防6个月死亡率的保护因素.
结论:
- 自身免疫性脑炎和内感染是GCSE向SRSE进展的重要风险因素.
- 在GCSE患者中,NLR作为住院和6个月死亡率的独立预测因子.
- 血交换在减少GCSE患者的长期死亡率方面具有有益作用.
更多相关视频
08:43Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System
Published on: July 21, 2015
25.6K
09:16Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury
Published on: June 21, 2019
25.6K
相关概念视频
Seizures: Classification
368
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
368
Arteries of the Lower Limbs
190
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
190
Electroconvulsive Therapy
41
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
41
