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Updated: Jul 7, 2025

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
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通过动态针注射IK1可以在对hiPSC衍生的心肌细胞的补丁针研究中产生全部差异

Arie O Verkerk1,2, Ronald Wilders1

  • 1Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.

Frontiers in physiology
|December 28, 2023
PubMed
概括

动态技术通过模仿向内调整器电流 (IK1) 来改善人类诱导的干细胞衍生的心肌细胞 (hiPSC-CMs). 这种方法产生静止的hiPSC-CMs,具有生理休息潜力,对于精确的离子通道研究至关重要.

关键词:
在GNB5中,GNB5是指GNB5.这是SCN5A.目前使用的乙胆激活.在去极化后的延迟.快速的电流是目前的.内向整流器的电流向内整流器的电流向内被触发的行动潜力.腹腔动作潜力是什么意思

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Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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