自动反应性抗体的独特模式与特定器官免疫相关的不良事件相关
Mehmet Altan1, Quan-Zhen Li2, Qi Wang3
1Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Frontiers in immunology
|December 28, 2023
概括
在免疫检查点抑制剂治疗期间,先前存在的自身反应性抗体可以预测器官特异性免疫相关不良事件 (irAEs). 像ACHRG IgM这样的特定抗体与肺炎相关,有助于识别免疫治疗患者的风险.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 免疫检查点抑制剂 (ICI) 彻底改变了癌症治疗,但可以引起与免疫相关的不良事件 (irAEs).
- 预先存在的自动反应性抗体在预测irAEs中的作用仍然不清楚.
- 了解这些抗体可能会改善患者风险分层和管理.
研究的目的:
- 调查基线自身反应性抗体概况与接受双重ICI治疗的患者中器官特异性irrAEs的发展之间的关联.
- 确定潜在的抗体生物标志物,以预测免疫疗法先验非小细胞肺癌患者的irAEs.
主要方法:
- 从58名接受过免疫治疗的转移性非小细胞肺癌患者的血样本进行了长度分析,这些患者接受了伊皮利姆巴和尼沃姆巴的治疗.
- 使用蛋白质微阵列来评估IgG和IgM对120个抗原的反应性,在基线和iRAE期间.
- 与特定的irAEs相关的自身抗体模式,如肺炎,皮肤炎和肝炎.
主要成果:
- 基线时明显的自身抗体模式与随后的器官特异性irrAEs有显著的关联.
- 较高的ACHRG IgM水平与肺炎相关.
- 反细胞克拉丁19IgM和抗thyroglobulinIgG与皮肤炎和肝炎有关,分别.
结论:
- 预先存在的自动反应性抗体在ICI治疗中作为irAEs的潜在预测生物标志物.
- 特定抗体 (ACHRG IgM,抗细胞素19 IgM,抗甲状腺蛋白 IgG) 需要进一步调查,以确定和监测irAE风险.
- 这项研究可以通过识别高风险患者群体,带来个性化免疫疗法策略.
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