在双胞胎怀孕中胎儿性变态和孕前
Rebekah E Brown1, Akaninyene I Noah1, Ashley V Hill2
1Department of Obstetrics and Gynecology, Division of Basic Science and Translational Research (R.E.B., A.I.N., B.D.T.), The University of Texas Medical Branch, Galveston.
Hypertension (Dallas, Tex. : 1979)
|December 28, 2023
概括
胎儿的性别会影响双胞胎怀孕中早产前风险. 与女性/女性对相比,女性/男性对的风险更高,这表明怀孕并发症中的性二态.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 生殖健康 生殖健康
背景情况:
- 妊娠的高血压疾病,包括妊娠前,与成人心血管疾病有关.
- 胎儿的两性变异在单独怀孕中被注意到,但在双胞胎中没有研究过.
- 双胞胎怀孕在了解怀孕并发症方面存在独特的挑战.
研究的目的:
- 调查胎儿性别配对与双胞胎怀孕中妊娠高血压疾病之间的关联.
- 为了确定胎儿的性别是否会影响双胞胎产前症和相关疾病的风险.
主要方法:
- 对1032例双胞胎怀孕 (2011-2022) 的回顾性队列研究.
- 胎儿的性别配对分为女性/女性,男性/男性和女性/男性.
- 修改Poisson回归用于评估高血压疾病的相对风险.
主要成果:
- 与女性/女性对相比,女性/男性双胞胎对与早产前的风险增加有关 (RR 2.01).
- 对于患有高血压疾病的男性/男性夫妇,没有发现显著的关联.
- 分析的特定高血压疾病包括孕期高血压和叠加的孕前.
结论:
- 有证据表明,胎儿的性变态影响女性/男性双胞胎对的早产子宫前风险.
- 需要进一步的研究来阐明潜在的生物机制.
- 研究结果强调了在管理双胞胎怀孕时考虑胎儿性别的重要性.
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