饮食维生素K1摄入量和发生的大动脉狭窄症
Carl J Schultz1,2, Frederik Dalgaard3, Jamie W Bellinge1,2
1School of Medicine (C.J.S., J.W.B., M.S., C.P.B., J.R.L., J.M.H.), University of Western Australia.
Arteriosclerosis, thrombosis, and vascular biology
|December 28, 2023
概括
饮食中摄入更多的维生素K1可能会降低大动脉狭窄的风险. 这项研究发现,维生素K1摄入量最高的个体患上大动脉狭窄和相关并发症的发病率较低.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 血管生物学 血管生物学
背景情况:
- 叶片化是大动脉狭窄症发展和进展的关键因素.
- 维生素K (K1) 在激活血管化抑制剂方面发挥作用,并可能影响炎症和骨质损失.
研究的目的:
- 研究饮食维生素K1摄入量与大动脉狭窄发生率之间的关联.
- 确定较高的维生素K1摄入量是否与大动脉狭窄及其并发症风险降低有关.
主要方法:
- 利用了来自丹麦饮食,癌症和健康研究的数据,其中包括55545名50-64岁的参与者.
- 使用食物频率调查问卷估计的习惯性维生素K1摄入量.
- 通过全国性的登记,前性地跟踪参与者,以确定发生的主动脉狭窄和随后的并发症.
主要成果:
- 在最长21.5年的时间里,1085名参与者被诊断患有大动脉狭窄,615人经历了并发症.
- 摄入维生素K1的最高五分位数与大动脉狭窄风险降低23%有关 (HR,0.77 [95% CI,0.63-0.94]).
- 维生素K1摄入量最高的参与者显示,主动脉狭窄并发症的风险降低了27% (HR,0.73 [95% CI,0.56-0.95]).
结论:
- 高摄入维生素K1丰富的食物与大动脉狭窄的发病率降低有关.
- 较高的维生素K1摄入量与较低的大动脉狭窄和其严重并发症风险相关.
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