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五种基于酸的根运河密封剂对多种工程生物膜的抗菌活性:一种体外研究

Wajih Hage¹, Dolla Karam Sarkis², Mireille Kallasy³

¹Department of Endodontics, Saint-Joseph University, Beirut, Lebanon. Phone: +961 70 188796,

The journal of contemporary dental practice

|December 28, 2023

概括

这项研究将五种根管密封剂与多种内牙生物膜进行了比较. 所有密封剂都显示出抗菌活性,Sealite显示出最一致的有效性,尽管在两组之间没有发现显著差异.

科学领域:

牙周内科医院牙周内科医院牙周内科医院
微生物学微生物学
生物材料科学生物材料科学

背景情况:

牙内膜生物膜在根管治疗中构成了重大挑战.
有效的根管密封剂对于消除持续的微生物感染至关重要.
了解各种密封剂的抗菌疗效对于成功的内牙结局至关重要.

研究的目的:

为了比较五种根管密封剂 (CeraSeal,总填充BC密封剂,Bio-C密封剂,AH Plus生物陶,K-Biocer) 对消除多种内牙生物膜的影响.
为了评估这些密封剂在应用后3,7和14天的抗菌活性.
确定不同生物陶密封剂对关键内牙病原体的比较有效性.

主要方法:

从没有腐烂的前骨中制备牙盘.
用多种生物膜 (Enterococcus faecalis,Proteus mirabilis,Pseudomonas aeruginosa,Candida albicans) 接种基亚帕提特盘的方法.
将CeraSeal,总填充BC密封剂,Bio-C密封剂,AH Plus生物陶,K-Biocer和Sealite应用于生物膜,与负控制组一起,然后在3,7和14天进行微生物分析.

主要成果:

在第3天和第14天之间,所有海鱼的总细菌数量显著下降 (p < 0.05).
在不同海动物群体之间在任何时间点都没有发现总细菌数量,E. faecalis或P. mirabilis数量的统计学上显著差异.
密封剂表现出不同的有效性,其中Sealite显示出最一致的细菌数量减少,并与生物陶组相比显著减少C.albicans.

结论:

所有测试的根管密封剂在14天内都对多种生物膜表现出抗菌活性.
虽然Sealite显示出最一致的有效性,但在海动物群体中没有观察到细菌减少的统计学上显著差异.
这些发现强调了密封剂抗微生物特性对内牙治疗临床成功的重要性.

关键词:

生物陶是生物陶中的一种.生物膜是一种生物膜.基于酸的根管密封剂多种生物膜.

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Biofilms

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...