父亲和母亲的预先怀孕和母亲的怀孕,尿液中的 parabens 度与儿童行为相关
Jordana Leader1, Lidia Mínguez-Alarcón2, Paige L Williams3
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Andrology
|December 28, 2023
概括
在受孕前,父亲暴露在基和甲基 parabens 与儿童增加的行为问题有关. 这些发现凸显了环境化学物质暴露对儿童神经发育的潜在风险.
科学领域:
- 环境健康 环境健康
- 发展性毒理学 发展性毒理学
- 流行病学 流行病学
背景情况:
- 有限的研究存在于父母的先入为主的帕拉本暴露和儿童的行为.
- 新出现的证据表明,对的暴露可能会影响后代的神经发育.
研究的目的:
- 为了调查母亲和父亲的预先怀孕,以及母亲怀孕在尿液中的度和儿童行为之间的关联.
- 检查了甲基,基和丁基的含量.
主要方法:
- 6-13岁儿童的前性队列研究 (预设环境暴露和儿童健康影响研究)
- 通过使用线性回归和量子式g计算,分析了局部转换的尿类度 (预孕和怀孕).
- 使用儿童行为评估系统-3和执行功能T分数的行为评分库对孩子的行为行为进行了评估.
主要成果:
- 较高的父亲预孕尿和甲基的度与增加的内化问题和行为症状指数T-分数相关.
- 父亲混合三种类型的与增加内化问题和行为症状有关.
- 甲与更高的执行功能元认知指数得分相关,但混合物没有.
结论:
- 父亲对基和甲基 parabens 的暴露与不良的儿童行为有关.
- 研究结果表明,父亲暴露于类和神经发育结果之间存在联系.
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