ProGlycProt V3.0:对 prokaryotic 糖蛋白及其糖系转移酶的最新见解
Shreya Janhvi1, Shikha Saini1, Vaidhvi Singh1
1CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh 160036, India.
Glycobiology
|December 28, 2023
概括
ProGlycProt版本3.0增强了对 prokaryotic 蛋白质糖化酶的研究. 此更新包括新的专利数据,改进的结构模型,以及从蛋白质组学数据集中扩展的糖蛋白条目.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 生物信息学是一种生物信息学.
背景情况:
- Prokaryotes 中的蛋白质糖化对各种细胞功能至关重要.
- 人们对微生物糖蛋白及其相关酶越来越感兴趣,这体现在出版物和专利的增加中.
- 现有的数据库可能缺乏关于 prokaryotic glycosylation 的全面,经过实验验证的数据.
研究的目的:
- 更新和扩展ProGlycProt数据库,提供最新的实验验证的关于 prokaryotic 蛋白质糖化酶的信息.
- 纳入关于糖基化方法,酶和相关技术的新数据,包括专利信息.
- 提高对策划数据的可访问性和实用性,为该领域的研究人员.
主要方法:
- 数据库库存实验验证的关于糖蛋白,糖系转移酶和辅助酶的信息.
- 使用质谱 (MS) 数据集集成来自 PRIDE 等公共数据库的数据.
- 包括与糖基化方法和技术相关的专利数据.
- 使用AlphaFold2模型重组和增强结构画廊.
主要成果:
- ProGlycProt 3.0 版本显著扩大了其范围,包括了新的专利信息和升级的结构模型.
- 添加了45个N-糖蛋白条目,从PRIDE MS数据集中注释并独立审查.
- 数据库现在涵盖了119种 prokaryotic 属,记录增加了67%,巩固了其作为综合资源的作用.
结论:
- ProGlycProt仍然是关于 prokaryotic 蛋白质糖化处理的实验验证数据的主要数据库.
- 持续更新确保研究人员能够获得最新和最全面的信息.
- 整合各种数据类型,包括专利和蛋白质组学数据,支持微生物糖化研究的进步.
关键词:
考古学是指古物质 (archaea) 是指古物质.细菌 细菌 细菌是一种细菌.葡萄糖蛋白质 (glycoproteins) 是一种葡萄糖蛋白质.葡萄糖酶化是什么? 葡萄糖酶化是什么?葡萄糖转移酶的使用方法更多相关视频
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