肠道微生物群对女性性激素状态的改变做出反应,并加剧代谢功能障碍
Tzu-Wen L Cross1,2,3,4,5, Abigayle M R Simpson1, Ching-Yen Lin2
1Department of Nutrition Science, Purdue University, West Lafayette, IN, USA.
Gut microbes
|December 28, 2023
概括
更年期会增加女性代谢功能障碍的风险. 由荷尔蒙变化改变的肠道微生物组有助于这种功能障碍,这表明针对微生物组的治疗可能有助于预防更年期相关疾病.
科学领域:
- 生殖生物学 生殖生物学
- 微生物学 微生物学
- 代谢健康 代谢健康
背景情况:
- 绝经后,女性面临更高的代谢功能障碍和慢性疾病的风险.
- 肠道微生物组在肥胖和代谢问题中的作用已知,但其与女性性激素和宿主代谢的相互作用尚不清楚.
研究的目的:
- 研究卵巢切除 (手术切除卵巢) 和高脂肪饮食对炎症和代谢表型以及肠道微生物群的影响.
- 通过便微生物移植 (FMT) 确定通过卵巢切除改变的肠道微生物组是否会导致代谢功能障碍.
主要方法:
- 在小鼠身上进行了卵巢切除和假手术,然后给予高脂肪或低脂肪饮食.
- 便微生物群移植 (FMT) 使用 gnotobiotic 小鼠进行,以从捐赠小鼠 (切除卵巢或完整) 转移肠道微生物群.
- 分析了炎症标志物,肠道透性,代谢参数和肠道微生物组合.
主要成果:
- 卵巢切除增加了胃肠道的通透性和炎症,而高脂肪饮食使炎症恶化.
- 卵巢切除改变了肠道微生物群,特别是在低脂肪饮食下显著增加了便β-glucuronidase活性.
- 从经过卵巢切除的供体 (在低脂肪饮食中) 接受肠道微生物群的小鼠表现出体重增加和与代谢功能障碍和炎症相关的肝脏基因表达.
结论:
- 肠道微生物群对女性性激素状况的变化敏感,在发展代谢功能障碍方面发挥作用.
- 准肠道微生物组以调节性激素效应可能为管理更年期相关疾病提供治疗策略.
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