在帕金森病中,认知和运动网络之间的神经合的变化与双重任务性能有关
Eunkyung Kim1,2, Seo Jung Yun1, Byung-Mo Oh1,3
1Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
概括
在帕金森病 (PD) 中,改变的大脑网络通信会影响步行. 特定的认知和运动网络相互作用预测双重任务步行表现,表明注意力缺陷的补偿机制.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 认知神经学 认知神经学
背景情况:
- 认知控制对步态至关重要,但其在帕金森病 (PD) 中的神经基础尚不清楚.
- 了解PD中的大脑网络相互作用对于步态评估至关重要.
研究的目的:
- 为了比较PD患者与对照者的认知和运动网络之间的互联网合.
- 研究这些网络合与PD中单任务和双任务条件下的步行表现之间的关系.
主要方法:
- 休息状态的功能性MRI识别了背部注意网络 (DAN),前侧对象控制网络 (FPN) 和运动网络.
- 通过在认知和身体双重任务条件下进行10米步行测试来评估步行表现.
主要成果:
- 与对照组相比,PD患者显示DAN/运动网络之间的合减少,左侧FPN/DAN/运动网络之间的合增加.
- 在PD中,互联网合和单任务/双任务步行表现之间没有发现直接相关性.
- 在高性能PD组中,DAN-左FPN合和认知双重任务性能之间存在正相关性;DAN-侧向电机网络合则相反.
结论:
- 研究结果表明,神经机制在认知控制有助于步行,补偿了PD中目标导向注意力减少的原因.
- 大脑网络动态提供了关于在帕金森病中维持双重任务步行表现的见解.
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