感染后6个月和12个月儿童的COVID-19后情况
Frederick Dun-Dery1, Jianling Xie2, Kathleen Winston1
1Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
JAMA network open
|December 28, 2023
概括
很少有儿童在SARS-CoV-2感染后出现COVID-19后疾病 (PCC),与未感染儿童相比,生活质量没有显著差异. 这项研究跟踪了儿科患者的长期结果.
科学领域:
- 儿科急救医学 儿科急救医学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 了解感染SARS-CoV-2的儿童的长期结果至关重要.
- 儿科人口中COVID-19后疾病 (PCC) 患病率需要量化.
研究的目的:
- 为了量化COVID-19后疾病 (PCC) 在儿童中测试SARS-CoV-2感染的患病率.
- 评估儿科患者感染后的长期症状和生活质量 (QoL).
主要方法:
- 一个多中心的前性队列研究在14个加拿大三级儿科急诊部 (EDs) 进行.
- 在2020年8月至2022年2月期间测试SARS-CoV-2的18岁以下儿童被跟踪了90天,6个月和12个月.
- PCC的定义是持续的症状和QoL减少,影响感染后3个月内日常功能.
主要成果:
- 在6个月的随访中,PCC存在于SARS-CoV-2阳性儿童的0.52%,相对于负控制组的0.10%.
- 在12个月的随访中,PCC在SARS-CoV-2阳性儿童的0.67%中存在,而在阴性对照中为0.16%.
- 在12个月的感染和非感染儿童之间没有观察到PedsQL得分的显著差异.
结论:
- 虽然感染SARS-CoV-2的儿童报告慢性症状增加,但很少有人患有PCC.
- 在12个月的SARS-CoV-2感染和没有感染的儿童之间,整体生活质量没有差异.
- 这项研究强调了儿童患儿ED的PCC发病率较低.
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