自免疫性疾病与与年龄相关的黄斑退化症的发展之间的关联
John Moir1, Max J Hyman2, Jessie Wang3
1Pritzker School of Medicine, University of Chicago, Chicago, Illinois, United States.
Investigative ophthalmology & visual science
|December 28, 2023
概括
与年龄相关的黄斑变性 (AMD) 与自身免疫性疾病共享免疫失调. 虽然大多数自身免疫性疾病不会增加AMD风险,但系统性红斑狼 (SLE) 和克罗恩病等特定疾病显示出适度的关联.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 与年龄相关的黄斑变性 (AMD) 病原包括免疫失调.
- AMD与自身免疫性疾病具有病原性相似之处.
- AMD 与大多数自身免疫性疾病之间的联系尚不清楚.
研究的目的:
- 调查自身免疫性疾病和新发年龄相关黄斑变性 (AMD) 之间的关联.
- 为了确定先前对自身免疫性疾病的诊断是否会影响发展AMD的可能性.
主要方法:
- 一项病例对照研究分析了2005-2019年55岁以上的新发 AMD 诊断 (ICD 代码) 的患者.
- 自免疫性疾病的诊断是基于在AMD诊断前12个月内ICD代码.
- 使用了根据AMD风险因素调整的条件多变量逻辑回归.
主要成果:
- 16.1%的AMD病例和15.9%的对照病例被诊断为自身免疫性疾病.
- 总的来说,自身免疫性疾病并没有显著改变AMD的几率 (OR=1.01).
- 盘状狼,SLE,巨细胞动脉炎,Sjogren综合征和克罗恩病与AMD的几率增加有关.
结论:
- 大多数自身免疫性疾病不会影响AMD的发展.
- 系统性红斑狼 (SLE) 和克罗恩病显示,AMD的几率略有增加.
- 需要进一步的研究来阐明这些关联背后的机制.
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