在患有2型糖尿病的年轻人中,胰岛素分泌,敏感性和功能
Petter Bjornstad1,2, Ye Ji Choi1,3, Carson Platnick1
1Section of Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
患有2型糖尿病的年轻人表现出显著的β细胞功能障碍,导致脏内的高血压和脏氧气水平的增加. 这些发现凸显了这一群体中损伤的潜在风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 年轻人患2型糖尿病与损伤风险增加有关.
- 贝塔细胞功能障碍和胰岛素抵抗是其中的关键因素.
- 青少年对脏血动力学和氧化的影响尚不清楚.
研究的目的:
- 调查贝塔细胞功能,胰岛素耐药性和2型糖尿病的年轻人参数之间的关系.
- 将这些参数与肥胖和正常体重对照进行比较.
主要方法:
- 研究了50名患有2型糖尿病的青少年,21名肥胖的对照者和20名正常体重的对照者.
- 方法包括对GFR和脏血流量的清除研究,对氧化的脏MRI,对胰岛素分泌和排放指数 (DI) 的高血糖,以及对身体组成的DXA.
主要成果:
- 与肥胖对照人群相比,患有2型糖尿病的年轻人对葡萄糖的DI和急性C-反应 (ACPRg) 显著降低,尿液中白蛋白与肌素的比率 (UACR) 和细胞内压力更高.
- 无论是2型糖尿病还是肥胖群体,GFR和脏氧气可用性 (相对高氧) 均高于正常体重对照组.
- 较低的DI与较高的球体内压力和脏过氧相关.
结论:
- 患有2型糖尿病的青少年表现出严重的β细胞功能障碍.
- 这种功能障碍与体内高血压和脏过氧有关.
- 肥胖的对照组显示了类似的,虽然不那么明显的变化.
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