系统治疗失败后晚期肝细胞癌的肝动脉输液疗法:多中心,现实世界的研究
Jun-Zhe Yi1, Zhi-Jian Zhu2, Gong-Wei Liu3
1Department of Minimally Invasive Interventional Therapy, Liver Cancer Study and Service Group, Sun Yat-sen University Cancer Center, Guangzhou, China.
概括
肝动脉输液化疗用牛利,5-甲,和leucovorin (HAIC-FOLFOX) 是一个可行的和安全的选择,对于先进的肝细胞癌 (HCC) 患者耐药的全身疗法. 这种治疗证明了可管理的不良事件,并支持其在这个具有挑战性的患者群体中的有效性.
科学领域:
- 在瘤学瘤学.
- 肝病学 肝病学是一种肝病学.
- 化疗 化疗是一种化学疗法.
背景情况:
- 晚期肝细胞癌 (HCC) 往往对标准的全身治疗,包括免疫检查点抑制剂和分子向药物具有耐药性.
- 需要采用替代治疗策略,以改善先进的HCC患者的治疗结果,这些患者已经耗尽了传统的选择.
研究的目的:
- 为了评估肝动脉输液化疗的可行性和安全性,使用牛氧,5-甲,和leucovorin (HAIC-FOLFOX).
- 评估HAIC-FOLFOX作为高级HCC患者的替代治疗方法,这些患者不耐系统治疗.
主要方法:
- 六个机构连续245名患有晚期HCC的病人接受HAIC-FOLFOX系统后治疗失败后的回顾性审查.
- 评估生存,瘤反应 (客观反应率,疾病控制率) 和耐受性 (不良事件).
主要成果:
- 在包括209名参与者中,中位总生存期 (OS) 为10.5个月,无进展生存期为6.0个月.
- 目标应答率为21.1%,疾病控制率为64.6%.
- 3-4级不良事件发生在28.2%的患者中,但可以控制,没有与治疗相关的死亡.
结论:
- 在先进的HCC患者中,HAIC-FOLFOX显示出有效性和良好的安全性,这些患者之前的全身治疗失败了.
- 这些发现支持HAIC-FOLFOX作为这种难以治疗的患者群体的可行治疗选择.
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