多发性硬化症相关的脑膜炎 - 来自印度南部的一系列
Kalpana Babu1, Geethanjali C Janardhana2, Krishna R Murthy1,2
1Department of Uveitis and Ocular Inflammation, Prabha Eye Clinic and Research Centre and Vittala International Institute of Ophthalmology, Bengaluru, Karnataka, India.
Indian journal of ophthalmology
|December 28, 2023
概括
这项研究详细介绍了印度7例多发性硬化症 (MS) 相关的脑膜炎,中级脑膜炎是最常见的形式. 这些发现突出了这种报告不足的疾病的临床特征和良好的视觉结果.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 遗传学 遗传学 是一个
背景情况:
- 多发性硬化症 (MS) 是一种慢性神经系统疾病.
- 在多发性硬化症患者中,可能会出现包括紫外炎在内的眼部表现.
- 与MS相关的脑膜炎被认为是报告不足的,特别是在印度.
研究的目的:
- 描述多发性硬化症 (MS) 相关的脑膜炎的临床特征.
- 来报道印度南部一家眼科三级医院的七例病例.
- 为了解印度次大陆这种报道不足的疾病做出贡献.
主要方法:
- 在2013年至2023年期间进行的回顾性案例系列.
- 对7例MS相关性脑膜炎确诊病例的临床数据的分析.
- 包括人口统计,临床表现,治疗和结果数据.
主要成果:
- 确定了7例 (五例女性,2例男性) 与多发性硬化症相关的脑膜炎.
- 中间性脑膜炎是最常见的呈现 (5例),通常伴有视网膜血管炎或圆盘白.
- 其他表现包括Fuchs异色色皮质环炎和不完整的Vogt-Koyanagi-Harada类综合征.
- 在一个案例中,全基因组测序发现了与MS易感性相关的TNFRSF1A基因变异.
- 所有患者都接受了全身类固醇;阿扎西奥普林和利图西马布是常见的免疫调节剂.
- 在最后一次随访时,在所有病例中都观察到良好的视觉结果.
结论:
- 多发性硬化症 (MS) 相关的脑膜炎在印度似乎被低诊断和低报告.
- 这一病例系列为印度人群中MS相关性脑膜炎的临床谱提供了宝贵的见解.
- 需要进一步的研究,以了解印度MS相关的脑膜炎的流行率和特征.
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