谷氨酸通过调节肠道微生物群和小猪的TLR4-p38/MAPK-NF-κB通路来减轻双A诱导的肠炎症
Zihao Liu1, Min Liu1, Huiru Wang1
1Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong Province 271018, China.
Ecotoxicology and environmental safety
|December 28, 2023
概括
谷氨胺 (Gln) 补充剂可缓解肠道炎症和肠道微生物群不平衡,这些不平衡是由于生猪暴露在双甲 (BPA) 中引起的. Gln通过调节炎症途径和有益细菌,有助于恢复肠道健康.
科学领域:
- 环境毒理学环境毒理学
- 动物营养 动物营养
- 胃肠病学 胃肠病学
背景情况:
- 双A (BPA) 是一种广泛存在的环境毒素,影响动物和人类的健康.
- 在暴露于BPA的人群中,肠道炎症和微生物群失生症是很重要的问题.
- 谷氨酸 (Gln) 在维护肠道完整性和免疫功能方面发挥着至关重要的作用.
研究的目的:
- 为了研究谷氨酸 (Gln) 对乙甲 (BPA) 诱导的肠炎症和小猪的微生物群变化的保护作用.
- 阐明 Gln 作用的潜在机制,包括其对炎症信号通路和肠道微生物组成的影响.
主要方法:
- 一项为期42天的养试验,涉及32只小猪,分为四组,含有不同水平的BPA和Gln补充剂.
- 评估生长性能,血清细胞因子水平,肠道组织病理学和炎症通路激活 (TLR4-p38 MAPK-NF-κB).
- 分析内微生物群组成和短链脂肪酸 (SCFA) 含量.
主要成果:
- 暴露于BPA显著损害了小猪的生长,诱导肠道炎症,并破坏了微生物群平衡.
- 食Gln补充剂改善了BPA挑战性猪仔的生长性能,并降低了血清促炎细胞因子.
- Gln使TLR4-p38 MAPK-NF-κB通路激活正常化,减轻粘膜损伤,调节肠道微生物群组成,增加有益细菌和SCFA.
结论:
- 谷氨胺 (Gln) 是一个关键的营养物质,可以减轻生猪的双甲 (BPA) 引起的肠炎症.
- Gln的保护作用部分通过调节肠道微生物平衡和抑制TLR4/p38 MAPK/NF-κB信号通路来调节.
- 这些发现突显了Gln在管理环境毒素引起的肠道障碍方面的治疗潜力.
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