评估全球结构性大脑年龄与成年早期精神分裂症多基因风险之间的关联:基因型回忆研究
Constantinos Constantinides1, Vilte Baltramonaityte1, Doretta Caramaschi2
1Department of Psychology, University of Bath, UK.
概括
对精神分裂症的遗传风险 (SCZ-PRS) 没有显示与年轻成年人的高级大脑年龄有关. 这表明大脑年龄可能并不表明精神分裂症的常见遗传脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 神经成像揭示了精神分裂症中大脑的晚年,这表明结构性衰老超出了时间学年龄.
- 精神分裂症的遗传责任与大脑晚年之间的联系尚未得到充分理解.
研究的目的:
- 调查精神分裂症 (SCZ-PRS) 的高多基因风险是否与年轻成年人的大脑晚年有关.
- 确定大脑年龄是否是精神分裂症常见遗传风险的潜在脆弱性标志物.
主要方法:
- 在基于人口的亚样本上使用了基因型回忆方法 (Avon长度研究父母和孩子).
- 评估了高SCZ-PRS和低SCZ-PRS的年轻成年人 (21-24岁) 的大脑年龄差异,使用MRI衍生的大脑结构测量机器学习模型进行评估.
- 根据扫描时的性别和年龄进行控制.
主要成果:
- 在高和低SCZ-PRS组之间没有发现大脑预测年龄减去时间年龄 (大脑-PAD) 的显著差异 (b = -21; p = .82).
- 结果表明SCZ-PRS与全球与年龄相关的结构性大脑模式之间没有关联.
结论:
- 研究结果不支持大脑年龄作为精神分裂症常见遗传风险的脆弱性标志物.
- 需要使用更大的样本和多模式大脑年龄测量的未来研究,以探索SCZ-PRS的潜在全球或局部影响.
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