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在两个纵向样本中,杏仁体发育的早期轨迹和晚期学龄焦虑之间的关联
Catherine A Burrows1, Carolyn Lasch2, Julia Gross3
1Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Developmental cognitive neuroscience
|December 28, 2023
概括
早期的大脑发育会影响以后的焦虑. 在患自闭症谱系障碍 (ASD) 的高风险组中,桃体的更快增长与焦虑相关. 在典型发育的儿童中,增长缓慢和杏仁体体积较小与焦虑有关.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 精神病学是一个精神病学.
背景情况:
- 杏仁体功能在自闭症谱系障碍 (ASD) 和焦虑病原发生过程中至关重要.
- 生命早期的大脑发育,特别是杏仁体的生长,可能预测以后的焦虑症状.
- 了解这些联系对于早期干预策略至关重要.
研究的目的:
- 研究早期杏仁体体积增长轨迹与学龄焦虑之间的关联.
- 为了比较这些协会在 ASD 的高家族概率的婴儿与典型的发育婴儿.
主要方法:
- 从新生儿到24个月的长度MRI扫描在两个队列:婴儿大脑成像研究 (IBIS) 和早期大脑发育研究 (EBDS).
- 线性多层次建模以评估杏仁体生长及其与焦虑的相关性,在6-12岁时进行评估.
- 分析ASD诊断和家族概率作为潜在的调节者.
主要成果:
- 在IBIS样本 (高ASD风险) 中,桃体加速生长 (6-24个月) 与更高的学龄焦虑有关.
- 在EBDS样本中 (典型的发育),杏仁体生长速度较慢和体积较小 (出生-24个月) 与焦虑增加有关.
- 自闭症诊断和家族概率并没有显著预测这些关联.
结论:
- 早期的杏仁体生长模式与以后的焦虑有着不同的关联,这取决于人群.
- 研究结果表明,在患有高ASD风险的儿童中,与正常发育的儿童相比,对焦虑的神经发育途径是不同的.
- 这项研究可能会确定在特定群体中将早期大脑发育与焦虑联系在一起的机制.
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