相关实验视频

Updated: Jul 6, 2025

Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

沙门氏菌T3SS引起的炎症性先天免疫反应抑制了巨细胞的I型IFN反应

Jingjing Tang¹, Yanchao Gu¹, Xiao Wang¹

¹State Key Laboratory of Crop Stress Biology for Arid Areas, Shaanxi Key Laboratory of Agricultural and Environmental Microbiology, College of Life Sciences, Northwest A&F University, Yangling, Shaanxi 712100, China.

Veterinary microbiology

|December 28, 2023

概括

沙门氏菌 Typhimurium 是一个类型.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
细菌病原体的产生

背景情况:

沙门氏菌 (Salmonella Typhimurium) 是一种感染巨细胞的グラム阴性病原体.
感染触发了促炎和I型干扰素 (IFN) 反应.
沙门氏菌的III型分泌系统 (T3SS) 激活炎症体,这些炎症体抑制I型IFN.

研究的目的:

调查S. Typhimurium T3SS在调节I型IFN反应中的作用.
阐明T3SS介导的天生的免疫调节背后的机制.

主要方法:

使用了T3SS有缺陷的S. Typhimurium突变体 (ΔinvC).
使用的卡斯巴酶-1 抑制剂 (VX-765,Z-VAD-FMK).
在指数和静止阶段细菌之间的比较反应.

主要成果:

具有T3SS缺陷的突变体显示炎症减少,但增强了I型IFN和ISG表达.
卡斯巴-1抑制增加了I型IFN反应.
静止阶段细菌诱导的IFN反应高于指数阶段细菌.

结论:

S. Typhimurium T3SS诱导的炎症抑制了I型的IFN反应.
这突显了T3SS在沙门氏菌感染期间调节先天免疫力的作用.

关键词:

在Caspase-1中,在炎症中,一些细胞会发炎.沙门氏菌是一种沙门氏菌.这就是T3SS.这是一种I型干扰子.

更多相关视频

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

相关概念视频

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...