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Updated: Jul 6, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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双刺激响应的输送系统用于自我调节的结肠向输送水溶性较差的药物

Mohmmad E Rabeh1, Lalitkumar K Vora1, Jessica V Moore1

  • 1School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.

Biomaterials advances
|December 28, 2023
PubMed
概括

这项研究开发了一种智能水凝,用于向结肠药物输送,改善炎症性肠病 (IBD) 治疗. 响应pH和酶的系统增强了药物在结肠中的释放,减少了全身副作用.

关键词:
亚二二烯是一种亚二烯.这是针对结肠的目标.克罗恩氏病 克罗恩氏病是什么?水凝是一种水凝.梅萨拉胺是一种美沙胺.甲尼达的使用方法

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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