精液病原体对标准精液参数,精子动力学和精液炎症标志物的影响
Artin Aghazarian1, Wolfgang Huf2, Hans Christoph Klingler3
1Department of Urology, Clinic Hietzing, Vienna, Austria; Department of Laboratory Medicine, Clinic Hietzing, Vienna, Austria.
Journal of reproductive immunology
|December 28, 2023
概括
精子病原体对精子质量产生负面影响,特别是Ureaplasma urealyticum. 细菌感染也可以引发炎症反应,影响无症状男性的生育能力.
科学领域:
- 生殖生物学 生殖生物学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 泌尿器官病原体与男性不孕症有关.
- 各种病原体对精液参数和炎症标志物的特定影响尚未完全阐明.
研究的目的:
- 评估特定的泌尿器官病原体对无症状子育男性的精液质量和炎症标志物的影响.
主要方法:
- 与六个病原体特定组的队列研究 (Ureaplasma urealyticum,混合,Gardnerella Vaginalis,グラム阳性菌/细菌,グラム阴性细菌,Chlamydia trachomatis),一个对照组和一个白细胞精子组.
- 分析标准精液参数,精子动力学,精液白细胞和介质素-6水平.
主要成果:
- 在大多数病原体群体中,标准精液参数显著受损,除了格拉姆阴性细菌.
- 尿,混合病原体和白细胞精子表现出对精子质量最显著的负面影响.
- 精子动力学,包括渐进性运动精子细胞的度和百分比和直度,在病原体存在时下降.
- 阳性菌/细菌和阴性细菌与增加的精液IL-6相关,而只有阴性细菌显著增加了精液白细胞.
结论:
- 精子病原体对精子质量和运动有不利影响.
- Ureaplasma urealyticum对精子参数的影响最大.
- 格拉姆阳性菌/细菌和格拉姆阴性细菌可以诱导精子炎症反应.
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