患有2型糖尿病患者中外围动脉疾病和糖尿病外围神经病变的危险因素
Tian Chen1, Shengjue Xiao1, Zhengdong Chen1
1Department of Cardiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Diabetes research and clinical practice
|December 28, 2023
概括
这项研究发现,在中国的2型糖尿病患者中,外周动脉疾病 (PAD) 和糖尿病外周神经病变 (DPN) 的高发病率. 识别年龄和高血压等危险因素是改善下肢健康的关键.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 周围动脉疾病 (PAD) 和糖尿病周围神经病变 (DPN) 是T2DM的常见微血管并发症.
- 了解不同人群中PAD和DPN的患病率和风险因素对于有针对性的干预至关重要.
研究的目的:
- 确定中国T2DM患者中PAD和DPN的患病率.
- 确定与PAD和DPN相关的独立风险因素.
- 探索聚类风险因素对疾病发病率的影响.
主要方法:
- 一项涉及13315名中国T2DM患者的横截面研究.
- 使用足-手臂指数 (ABI) 诊断的PAD≤0.9.
- 通过医生评估,问卷和振动感知值测试来评估DPN.
- 用于识别风险因素的物流回归分析.
主要成果:
- 患病率:PAD的4.9%和DPN的43.9%.
- PAD的独立风险因素包括晚年,吸烟,高血压,冠状动脉心脏病,血脂不良,HbA1c升高和尿酸.
- 独立的DPN风险因素包括晚年,女性性别,高血压,冠状动脉心脏病,脂质不良和各种代谢标志物;阿波利波蛋白A显示有保护作用.
- 风险因素的聚类显著增加了疾病风险.
结论:
- 这项研究强调了中国T2DM患者中PAD和DPN的显著流行率.
- 确定了关键的风险因素,为早期发现和干预提供了目标.
- 研究结果有助于改善下肢健康,并预防糖尿病患者的并发症.
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