基于家庭的双盲,安慰剂控制的挑战,用于诊断儿童延迟质/牛奶过敏症

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Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Vibeke Østberg Landaas¹, Håvard Ove Skjerven¹, Karin C Lødrup Carlsen¹

¹Division of Child and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

The journal of allergy and clinical immunology. In practice

|December 28, 2023

概括

家庭食品挑战 (H-FC) 有效地识别了延迟对谷蛋白或牛奶过敏的儿童,减少了不必要的消除饮食. 三个挑战期可以提高诊断食物敏感性的准确性.

科学领域:

儿科过敏和免疫学
临床营养学临床营养学
诊断方法诊断方法

背景情况:

对质和牛奶蛋白质的延迟过敏是常见的,但诊断很困难.
许多儿童由于诊断困难而进行不必要的消除饮食.

研究的目的:

评估家庭双盲安慰剂控制食品挑战 (H-FC) 在诊断儿童对谷蛋白和牛奶过敏的有效性.
为了确定H-FC是否可以减少长期排泄饮食的需要.

主要方法:

73名儿童 (年龄在1-17岁) 怀疑对质或牛奶有延迟反应,接受了随机的H-FC.
儿童在5-7天内以双盲交叉方式接受质/牛奶蛋白或安慰剂,并有洗期.
症状被记录下来,积极的挑战被定义为活跃期和安慰剂期的症状显著增加.

主要成果:

25%的儿童 (18/73) 的H-FC.阳性.
在2个挑战期 (35%) 和3个挑战期 (12%) 相比,观察到更高的积极挑战率.
80%的负面挑战儿童在随访时成功地重新引入了牛奶/质.

结论:

家庭食品挑战 (H-FC) 在避免儿童不必要的消除饮食方面表现有前途.
可能需要三个挑战期来最大限度地减少假阳性结果并提高诊断准确度.
H-FC可以帮助识别那些可以安全地将质和牛奶重新引入饮食中的儿童.

关键词:

孩子孩子孩子孩子诊断诊断诊断诊断诊断食物过敏食物过敏粮食挑战粮食挑战食物过敏性过敏性过敏性过敏性食物不耐受性食物不耐受性质蛋白是一种质.牛奶牛奶牛奶牛奶在NCGS中,NCGS是指NCGS.自己报告的自我报告.

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