乙烯氧化物水平与抑郁症状之间的关联:基于NHANES 2013-2018数据库的横截面研究
Huaicheng Wang1, Xuanjie Chen1, Fabin Lin2
1Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; Fujian Institute of Geriatrics, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou 350001, China; cFujian Key Laboratory of Molecular Neurology, Fujian Medical University, 88 Jiaotong Road, Fuzhou 350001, China; Fujian medical University, Fuzhou, China.
通过血红蛋白添加物 (HbEO) 测量的乙烯氧化物 (EO) 暴露与患抑郁症状的风险更高有关. 炎症因素可能会调解这种关联,突出了发展心理健康问题的潜在途径.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 神经科学是一个神经科学.
背景情况:
- 乙烯氧化物 (EO) 是一种广泛使用的工业化学品,具有已知的健康危害.
- 在EO暴露和抑郁症状之间的联系还不太清楚.
- 乙烯氧化物的血红蛋白添加物 (HbEO) 作为EO暴露的生物标志物.
研究的目的:
- 调查以HbEO水平显示的EO暴露与抑郁症状发生之间的关联.
- 探索EO暴露和抑郁症之间的关系中的潜在调解因素.
主要方法:
- 使用了后勤回归,受限立方线和子组分析.
- 进行调解效应分析以确定影响因素.
- 使用HbEO水平作为EO暴露的定量度量.
主要成果:
- 较高的HbEO水平与抑郁症状的风险增加有显著的关联.
- 在HbEO的最高四分位数中,抑郁症状的几率增加了3.37倍 (OR:3.37,95%CI:1.87-6.10).
- 观察到线性关联,并确定炎症因素和甘油三酸是显著的调解者.
结论:
- 较高的EO暴露与患抑郁症状的风险增加有关.
- 炎症反应可能在调解EO的神经毒性作用方面发挥关键作用,导致抑郁症.
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