在eosinophilic食道炎的组织学缓解后持续的食道变化
Melanie A Ruffner1, Tetsuo Shoda2, Megha Lal3
1Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa; Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, Pa.
The Journal of allergy and clinical immunology
|December 28, 2023
概括
缓解期的性食道炎 (EoE) 患者表现出持续的食道基因表达变化. 这些发现表明表观遗传机制可能会导致EoE复发,即使没有症状.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 性食道炎 (EoE) 涉及到持续的过敏性炎症.
- 了解EoE复发机制对于预防长期并发症至关重要.
研究的目的:
- 为了确定食道基因表达是否在达到组织学缓解的EoE患者中保持失调.
主要方法:
- 使用EoE诊断面板 (94个转录) 来进行儿科和成人EoE缓解期患者食道活检的分子分析.
- 与对照对象进行比较.
主要成果:
- 在儿科 (51个基因) 和成人 (32个基因) 缓解的EoE患者 (<15eos/hpf) 中观察到显著的基因表达差异.
- 即使有严格的缓解 (0eos/hpf),25个儿科和18个成人基因仍有差异表达.
- 在缓解期的EoE患者中,CDH26被上调,在成人中,POSTN表达与内镜评分相关.
结论:
- 持久的EoE相关基因表达发生在患有深度缓解的患者中.
- 炎症诱导的表观遗传变化可能会影响EoE缓解期间的基因表达.
- 这些发现提供了对EoE复发背后潜在机制的见解.
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