在SARS-COV-2病毒感染后,慢性淋巴细胞白血病的过程
I S Dyagil1, I V Abramenko1, Z V Martina1
1State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka St., Kyiv, 04050, Ukraine.
Problemy radiatsiinoi medytsyny ta radiobiolohii
|December 28, 2023
概括
这项研究表明,SARS-CoV-2感染可能对慢性淋巴细胞白血病 (CLL) 产生负面影响,可能使现有病例恶化或引发新的诊断. 疫苗接种 疫苗接种
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 辐射瘤学 辐射瘤学
背景情况:
- 慢性淋巴细胞白血病 (CLL) 是一种B细胞恶性瘤.
- 感染SARS-CoV-2对CLL患者的影响,特别是那些先前暴露于电离辐射 (IR) 的人,需要进行调查.
研究的目的:
- 在SARS-CoV-2感染后的患者中调查CLL的过程.
- 评估之前的IR暴露对COVID-19后CLL进展的影响.
主要方法:
- 从2020年1月到2023年8月对51名CLL患者的回顾性分析.
- 包括不同程度的IR暴露患者 (切尔诺贝利清理工人,受污染地区居民,IR非暴露).
- 通过临床病史,淋巴细胞形态学和免疫表型标准确认诊断;通过PCR确认SARS-CoV-2感染.
主要成果:
- 在14名患者中新诊断出CLL,其中7例发生在SARS-CoV-2感染后2至17个月,经常呈现出明显的淋巴腺病,需要早期治疗.
- 13名现有CLL患者感染了COVID-19;53.8%需要开始治疗或显示CLL进展.
- 四名接种疫苗的患者患上了SARS-CoV-2感染,两名在接种疫苗后1-2个月内经历了CLL复发.
结论:
- 感染SARS-CoV-2可能会对新的慢性淋巴细胞白血病和之前存在的慢性淋巴细胞白血病的过程产生负面影响.
- 这项研究强调了SARS-CoV-2感染和CLL进展之间的潜在联系,特别是在有过电离辐射暴露史的人群中.
- 在CLL患者中接种SARS-CoV-2疫苗的作用仍然不确定,需要进一步调查.
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