胸部手术后肝功能障碍的患病率和临床相关性:一项回顾性研究
Rosanna Villani1, Domenico Loizzi2, Antonia Federica Sacco3
1C.U.R.E. (University Center for Liver Disease Research and Treatment), Liver Unit, Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122, Foggia, Italy. rosanna.villani@unifg.it.
Scientific reports
|December 28, 2023
概括
胸部手术可能导致肝功能障碍,37.5%的患者显示氨酸转移酶 (ALT) 升高,53.6%显示胺转移酶 (GGT) 升高. 较长的手术时间增加了风险,而甲胺使用则降低了风险.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胸部外科手术 胸部外科手术
- 临床生物化学 临床生物化学
背景情况:
- 手术后的肝功能障碍在肝脏和心脏手术后很常见.
- 胸部手术后高转胺血症的患病率和临床意义尚不清楚.
- 与胸外手术相比,胸部手术可能会带来不同的肝功能障碍风险.
研究的目的:
- 确定胸部手术后肝功能测试异常的频率和严重程度.
- 为了识别与术后高血胺血症相关的危险因素.
- 为了研究甲胺对肝酶升高后胸部手术的影响.
主要方法:
- 对224名接受胸部手术的患者进行了回顾性分析.
- 在手术前和手术后多个时间点监测肝功能测试 (ALT,GGT, bilirubin,INR).
- 统计分析以确定手术因素和肝酶升高之间的关联.
主要成果:
- 37.5%的患者经历了阿氨酸转移酶 (ALT) 水平的升高.
- 53.6%的患者表现出马-氨基转移酶 (GGT) 水平的增加.
- 手术时间与超氨酸血症有关;甲福林使用与ALT增加的风险降低有关. 大多数升高都是轻微的 (1或2级).
结论:
- 胸腔手术经常与肝酶 (ALT和GGT) 的短暂,轻微升高有关.
- 长时间的手术时间是高转胺血症的危险因素.
- 甲福明可能对胸部手术患者的术后ALT升高具有保护作用.
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