在状细胞肉瘤患者中建立和验证总生存率和癌症特异性生存率的诺莫格拉姆模型
Weihui Qi1,2, Yanyun Ren3, Huang Wang1,2
1Department of Orthopaedics, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, 310000, Zhejiang, People's Republic of China.
Scientific reports
|December 28, 2023
概括
这项研究开发了名图来预测状细胞肉瘤 (SCS) 患者的整体存活率 (OS) 和癌症特异性存活率 (CSS). 这些工具具有高精度的验证,可以帮助个性化预后和罕见的SCS病例的临床决策.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 生物统计学 生物统计学
背景情况:
- 状细胞肉瘤 (SCS) 是一种罕见的恶性瘤,预后工具有限.
- 准确预测整体存活率 (OS) 和癌症特异性存活率 (CSS) 对患者管理至关重要.
研究的目的:
- 开发和验证用于预测状细胞肉瘤患者的OS和CSS的诺莫格拉姆模型.
- 确定影响SCS.生存结果的独立预后因素.
主要方法:
- 从SEER数据库中提取了1369名螺旋细胞肉瘤患者 (2004-2020) 的数据.
- 考克斯回归分析确定了预后因素;使用C指数,ROC曲线,校准曲线和DCA构建和验证了名图.
- 卡普兰-梅尔曲线和日志排名测试比较了不同患者组的生存率.
主要成果:
- 年龄,阶段,等级,瘤位置,手术,放射和诊断年份是OS的独立预后因素.
- 年龄,阶段,等级,瘤位置和手术是CSS的独立预后因素.
- 开发的诺姆图表显示出高的预测准确性 (C指数为0.76-0.78) 和临床实用性.
结论:
- 已建立的诺姆图为状细胞肉瘤患者提供准确,个性化的预后预测.
- 这些工具可以帮助临床医生做出明智的SCS治疗和管理决策.
- 手术仍然是状细胞肉瘤的主要治疗方式.
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