一项关于2型糖尿病治疗的多中心观察性研究,规定治疗模式和患者对治疗的坚持
Muhammad Daoud Butt1,2, Siew Chin Ong3, Azra Rafiq4,5
1Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.
Scientific reports
|December 28, 2023
概括
巴基斯坦的糖尿病治疗显示出对指导方针的不严格遵守,尽管有多药,但血糖失控率很高. 改善国家行动计划和患者教育对于更好的糖尿病管理至关重要.
科学领域:
- 内分泌学和代谢性疾病.
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
背景情况:
- 巴基斯坦的糖尿病患病率很高 (2021年为9.6%),超过了全球平均水平.
- 巴基斯坦对遵守国际治疗指南和口服抗糖尿病 (OAD) 处方模式的了解仍然不充分.
- 鉴于糖尿病的全球和国家负担日益增加,有效的糖尿病管理至关重要.
研究的目的:
- 调查巴基斯坦的抗糖尿病药物处方做法.
- 分析生活方式改变,处方药和血糖控制之间的关联.
- 评估当前治疗方法在维持巴基斯坦糖尿病患者理想血糖水平方面的有效性.
主要方法:
- 一项涉及巴基斯坦农村和城市三级护理医院388名门诊患者的横截面研究.
- 从2021年10月到2022年2月,通过采访采用预先验证的问卷收集的数据.
- 使用奇平方测试进行双变量分析,以确定治疗坚持,临床和人口统计因素之间的关系.
主要成果:
- 超过60%的患者有不受控制的禁食和随机血糖水平.
- 52.1%的人表现出HbA1c水平高于国际糖尿病联合会的治疗值,尽管每处方平均有5.08种药物.
- 在64.6%的病例中,处方趋势主要有利于传统的OAD (比瓜尼德,硫尿素,DPP-4抑制剂).
结论:
- 巴基斯坦的处方做法偏离了国际和国家指导方针,导致失控的糖尿病和多药.
- 血糖控制和BMI,生活方式遵守和药物数量之间存在显著的关联.
- 迫切需要制定国家糖尿病行动计划,加强患者教育,重点关注改善糖尿病管理的生活方式改变.
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