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照亮:对多发性硬化症补充剂的元分析

Mehrab Rahmani¹, Sina Pakkhesal¹, Saman Baharomid¹

¹Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Biological trace element research

|December 28, 2023

概括

超过10%的多发性硬化症 (MS) 患者使用补充剂,但目前的证据不支持其有效性或安全性. 需要更多的研究来确定补充在MS护理中的好处.

科学领域:

神经学神经学
营养科学营养科学
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 是一种慢性,免疫媒介的中枢神经系统疾病.
是一种微量元素,具有强大的抗氧化特性.
了解在MS中的作用对于患者管理至关重要.

研究的目的:

系统地审查和对多发性硬化症患者补充的证据进行元分析.
评估MS中和含补充剂的消费率,有效性和安全性.
确定有关和MS的当前研究中的差距.

主要方法:

在PubMed,科学网,Scopus和Embase上进行系统的文献搜索.
使用全面元分析软件进行元分析.
使用Joanna Briggs研究所的批判性评估工具进行偏见风险评估.
包括9项研究,包括6项关于消费率的研究 (2381名患者) 和3项关于安全性/有效性的RCT.

主要成果:

大约14.3%的MS患者目前使用补充剂,11.3%以前使用过它们.
没有证据支持单独补充在MS的疗效.
三项RCT表明含补充剂的安全性,可能改善炎症和氧化应激.

结论:

超过10%的多发性硬化症患者使用补充剂,但临床益处尚未确定.
关于MS中补充剂的安全性和有效性的有力证据显著缺乏.
需要进一步进行高质量的临床试验,以澄清在多发性硬化症中的作用.

关键词:

食补充剂食补充剂食补充剂进行元分析分析.微量营养素微量营养素微量营养素多发性硬化症是多发性硬化症.是一种.系统性审查系统性审查

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