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通过"剂量效应加权系数"探索Belamcanda Chinensis的喘机制 网络药理学和实验验证
Kaiyue Zhang1, Jingwei Lv1, Jiaming Shen1
1Department of Jilin Institute of Ginseng Science, Changchun University of Chinese Medicine, Changchun 130114, China.
Combinatorial chemistry & high throughput screening
|December 29, 2023
概括
贝拉姆坎达中国菌 (BC) 通过网络药理学识别关键标和活性化合物,显示出对喘的保护作用. 这项研究为选天然产品成分用于喘治疗提供了一种新的方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 网络药理学 网络药理学
背景情况:
- 喘是一种慢性呼吸道炎症疾病,对健康有重大影响.
- 贝拉姆坎达中药 (BC) 是一种传统的中医药,具有与喘治疗相关的抗炎和免疫调节性质.
研究的目的:
- 为了研究贝拉姆坎达中国 (BC) 在治疗喘中的作用机制.
- 建立一个"剂量效应加权系数"网络药理学方法来预测活性化合物.
主要方法:
- 使用UPLC-QEOrbitrap-MS光谱测量来分析BC组件.
- 网络药理学方法集成了BC含量,生物可用性和分子对接,以确定关键目标和途径.
- MTT和ELISA测定验证了活性成分对16HBE细胞增殖的影响.
主要成果:
- 贝拉姆坎达中国 (BC) 在16HBE喘模型上显示出保护作用.
- 确定的主要目标包括SYK,AKT1和ALOX5,其中FcepsilonRI作为一个重要的信号通路.
- 确定了8种活性化合物,包括tctoridin和mangiferin,其中5种促进16HBE细胞增殖,并作为潜在的质量标志物.
结论:
- 这项研究提出了一种新的虚拟和实用的方法,用于快速选天然产品中的活性成分.
- 这些发现支持使用Belamcanda chinensis (BC) 治疗喘,并提供潜在的质量标志物.
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