临床风险因素和风险评估模型 门癌切除术后门癌泄漏
1Department of Gastrointestinal Surgery, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
Indian journal of cancer
|December 29, 2023
概括
这项研究确定了直肠癌手术后道泄漏 (AL) 的关键风险因素,开发了一个预测模型,将患者分为高,中和低风险组,以便更好地进行手术规划.
科学领域:
- 结肠直肠手术 结肠直肠手术
- 手术瘤学手术瘤学
- 临床风险评估临床风险评估
背景情况:
- 截面泄漏 (AL) 是直肠癌手术后的一个关键并发症.
- 现有的关于AL风险因素的研究缺乏最终的共识.
- 这项研究旨在确定AL预测因子,并开发一种预测工具.
研究的目的:
- 为了确定直肠癌切除后的解肠口腔泄漏 (AL) 的独立风险因素.
- 开发和验证一个风险评估模型来预测AL.
- 帮助临床决策,尽量减少AL并发症.
主要方法:
- 对276名接受直肠癌前切除术的患者 (2015-2020年) 的回顾性分析.
- 使用单变量和多变量逻辑回归评估24个变量.
- 基于已识别的独立风险因素构建风险评估模型.
主要成果:
- 在7.2%的患者中发生了解剖管泄漏.
- 关节炎的独立风险因素包括外科手术期间的骨,瘤大小≥5厘米,瘤距离门边缘<7.5厘米,以及肥胖.
- 一个转向的口腔被确定为一个保护因素.
- 风险模型将患者分为高 (61.5%的AL),中等 (11.9%的AL) 和低 (2.0%的AL) 风险组.
结论:
- 开发的风险评估模型准确地识别了高风险的患者.
- 该模型可以协助临床决策,以减轻不良结果.
- 该工具支持主动管理策略,以减少AL发病率.
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