在老年人中,结构性大脑MRI异常与之间存在关联
James J Gugger1, Alexa E Walter1, Ramon Diaz-Arrastia1
1Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Annals of clinical and translational neurology
|December 29, 2023
概括
大脑MRI异常,如灰色和白质病理学,与老年人新发性有关. 这些变化出现在发作开始之前,这表明神经退行功能在晚发风险中的作用.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 流行病学 流行病学
背景情况:
- 晚发性 (LOE) 影响老年人,其潜在原因尚未完全理解.
- 大脑MRI是调查大脑结构变化的关键工具.
研究的目的:
- 确定大脑MRI异常与老年人发病率之间的关联.
- 调查灰色和白质变化是否在晚发性中先发作发作.
主要方法:
- 在社区动脉样硬化风险研究中利用了1251名参与者 (45-64岁) 的脑部MRI数据.
- 在MRI采集后,对事件晚发性 (LOE) 进行了跟踪,分析皮质厚度,皮质下体积和白质完整性.
- 用人考克斯比例危险回归,调整人口统计和心血管风险因素.
主要成果:
- 2.2%的参与者在MRI后发生了LOE,平均时间为6.4年.
- 发生LOE的个体在发作发作之前表现出更大的皮质稀释和白质异常.
- 增加的灰质病理 (HR:2.3) 和白质扩散异常 (HR:3.0) 与事件LOE相关.
结论:
- 显著的灰色和白质病理在患有LOE的个体中是明显的.
- 这些神经退行变化在发作临床表现之前就已经存在.
- 这些发现突出了神经退行症在晚发风险中的作用.
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