性受限的实验进化驱动了一种雌雄性动物的转录基因分歧
Aivars Cīrulis1,2,3, Anna K Nordén1, Allison M Churcher4
1Department of Biology, Lund University, 223 62 Lund, Sweden.
Genome biology and evolution
|December 29, 2023
概括
这项研究揭示了性染色体和不同性别的早期进化涉及基因表达的显著变化,特别是丸偏差基因,在实验进化期间在Macrostomum lignano.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 发育生物学是发展生物学.
背景情况:
- 从雌雄性转变为雌雄性转变涉及性染色体的形成和性别偏差的基因表达.
- 性选择被假设是驱动男性偏向的基因表达进化.
- 以前的研究依赖于理论模型或古代的性别染色体.
研究的目的:
- 研究早期性染色体进化过程中的基因表达变化.
- 在性别有限的实验进化下检查适应性基因表达.
- 了解性别偏差基因表达在性病的演变中的作用.
主要方法:
- 在三个选择制度下,同时发生的雌性异性动物Macrostomum lignano的实验进化:雌性适应性,雄性适应性和控制.
- 整个生物体基因表达变化的表征在21-22代后发生变化.
- 基因本体学和基因和基因组路径分析的京都百科全书.
主要成果:
- 女性选择的基因系表现出基因表达中最实质性的变化.
- 代谢变化,包括氨基酸生物合成和碳代谢,被确定为关键的适应成分.
- 丸偏差基因候选者在女性选择的线路中表现出下调的趋势.
结论:
- 丸偏差基因表达的变化在性染色体和色体进化的早期阶段至关重要.
- 实验进化为性系统转变的遗传基础提供了洞察力.
- 代谢适应在应对受性别限制的选择压力方面发挥着重要作用.
相关概念视频
The Ratio of X Chromosome to Autosomes
8.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.5K
Dosage Compensation
6.2K
In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
6.2K
Background and Environment Affect Phenotype
6.5K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.5K
Exon Recombination
3.6K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.6K
X and Y Chromosomes
26.0K
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
26.0K
The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K


