<编辑选择> 在正常衰老中保留THK 5351的模式涉及与更高认知功能相关的静止状态网络的核心区域
Yusuke Yoshida1, Takamasa Yokoi2, Kazuhiro Hara1
1Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Nagoya journal of medical science
|December 29, 2023
概括
pozitron发射断层扫描 ([18F]THK 5351) 图像显示了健康的老年大脑中的星病模式. 这个标记器突出显示了中间前额叶皮层和基底,这些关键的连接器枢纽与认知网络相连.
科学领域:
- 神经成像是一种神经成像.
- 分子成像学分子成像学
- 大脑衰老研究研究
背景情况:
- 星和陶积累与神经退行性疾病有关.
- 像[18F]THK 5351这样的正子发射断层扫描 (PET) 追踪器为这些病理过程提供了洞察力.
- 了解[18F]THK 5351在健康衰老中的分布对于解释与疾病相关的变化至关重要.
研究的目的:
- 在健康的衰老中绘制星病标记物[18F]THK 5351的分布图.
- 为了研究THK 5351保留和内在大脑网络之间的关系.
- 为了确定健康的大脑衰老的潜在成像生物标志物.
主要方法:
- 62名健康参与者接受了MRI和PET扫描,包括[18F]THK 5351和匹兹堡化合物-B.
- 使用缩放式子概况建模/主要组件分析来确定THK 5351的分布模式.
- 基于种子的功能连接性分析使用静止状态fMRI数据进行.
主要成果:
- 最重要的[18F]THK 5351分布是在中部前额叶皮层和双边皮层中发现的.
- 中间前额叶皮层 [18F]THK 5351保留与背部默认模式网络相关.
- 普塔门[18F]THK 5351保留显示与基底和突出网络重叠,识别了连接器枢纽.
结论:
- [18F]THK 5351的与年龄相关的空间分布在健康衰老中的中枢前额叶皮质和基底质中被确定.
- 这些分布峰值位于连接器枢纽中,与大规模静止状态网络密切相关.
- 这些发现为老年大脑的结构和功能组织以及潜在的成像目标提供了洞察力.
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