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在印度的肺腺癌中可操作的基因组改变的景观

Rakesh Sharma¹, Aruna Priya Kamireddy², Syed Meera Hussaini¹

¹Sapien Biosciences Private Limited, Hyderabad, Telangana, India.

Frontiers in genetics

|December 29, 2023

概括

下一代测序在94%的印度肺腺癌患者中发现了可操作的遗传改变. 大多数病例都有可向突变,使得个性化肺癌治疗能够使用FDA批准的药物.

科学领域:

在瘤学瘤学.
遗传学是一个遗传学.
个性化医疗是个性化的医疗.

背景情况:

肺腺癌 (LUAD) 是全球癌症死亡的主要原因,生存率较低,特别是在印度.
下一代测序 (NGS) 和向疗法为基于分子形状的个性化LUAD治疗提供了新的途径.

研究的目的:

为了研究印度LUAD患者的分子格局,使用向的NGS.
为个性化治疗策略确定临床可操作的遗传变异.

主要方法:

对53个印度LUAD患者样本的回顾性分析.
针对46个癌症相关瘤基因的NGS面板测序.
使用OncoKB进行临床可操作性评估的变体注释.

主要成果:

在31个基因的94%样本中检测到致病变体.
最常见的突变:TP53 (52.8%) 和EGFR (50.9%).
79%的病例有可采取行动的变化,其中39.6%具有1级可采取行动 (FDA批准的药物可用).
EGFR Exon19删除和L858R是最常见的可向变异 (20.7%).

结论:

针对性的NGS对于识别印度LUAD患者可操作的分子变化至关重要.
这些发现支持个性化医疗,指导针对性治疗选择,以改善治疗结果.
该研究强调了与以前的LUAD研究相比,某些突变 (例如EGFR,ALK) 的患病率更高,KRAS突变更低.

关键词:

可起诉的变更是可以起诉的.生物标志物生物标志物分子景观的分子景观.这是下一代测序.非小细胞肺癌的肺癌.精准医学是一门精准医学.有针对性的治疗.

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