与代谢功能障碍相关的脂肪肝疾病与HF和AF风险的关联
Ryusei Ohno1, Hidehiro Kaneko1,2, Yuta Suzuki1,3
1Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
JACC. Asia
|December 29, 2023
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显著增加心力衰竭 (HF) 和心房动 (AF) 的风险. 这种新的肝病概念强调了解决MAFLD对心血管健康的重要性.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 流行病学 流行病学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种新出现的肝脏疾病.
- 心力衰竭 (HF) 和心房动 (AF) 的全球流行率不断增加,需要了解相关的风险因素.
- 关于MAFLD与发生的HF或AF之间的联系的研究有限.
研究的目的:
- 调查MAFLD与HF和AF发病率之间的关联.
- 与其他组相比,量化MAFLD患者的HF和AF风险.
- 探索MAFLD与其他心血管事件的关联.
主要方法:
- 利用了全国范围内的流行病学数据库,包括3,279,918名个人.
- 定义的代谢功能障碍 (超重,代谢综合征或糖尿病) 和脂肪肝疾病 (FLD).
- 将参与者分为四组:非FLD/非代谢功能障碍,代谢功能障碍,FLD和MAFLD.
主要成果:
- 与对照组相比,MAFLD与HF (HR 1.73) 和AF (HR 1.51) 的风险增加显著相关.
- 单独患有代谢功能障碍和单独患有FLD的个体也表现出HF和AF的风险增加.
- MAFLD显示心肌梗塞,胸痛和中风的风险更高,MAFLD亚型的风险不同.
结论:
- MAFLD与患心力衰竭和心房的风险增加密切相关.
- 这些发现强调了承认MAFLD作为一个独特的肝病实体的临床意义.
- 治疗MAFLD对于减轻心血管事件风险至关重要.
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