乳清蛋白对玛辐射诱导的舌头损伤的辐射保护潜力
Hanaa M Hassan1, Asmaa M Abdeen2, Ibrahim Y Abdelrahman3
1Department of Agricultural Chemistry, Faculty of Agriculture, Minia University, Minia, Egypt.
Frontiers in pharmacology
|December 29, 2023
概括
乳清蛋白分离物 (WP) 通过减少氧化应激和炎症来减轻玛辐射引起的舌头损伤. 用WP补充饮食可能为接受放射治疗的癌症患者提供辐射保护作用.
科学领域:
- 生物医学科学 生物医学科学
- 辐射保护 辐射保护
- 营养生物化学 营养生物化学
背景情况:
- 电离辐射 (IR) 是对口腔癌的关键治疗方法,但会对周围的健康组织造成重大损害.
- 乳清蛋白分离物 (WP) 是一种乳制蛋白,具有多种生物活性,具有潜在的治疗应用.
- 了解WP对辐射引起的组织损伤的保护作用对于改善癌症患者护理至关重要.
研究的目的:
- 评估乳清蛋白分离剂 (WP) 对大鼠语言组织的马辐射诱导损伤的辐射保护潜力.
- 研究WP保护作用的潜在机制,重点关注氧化应激和炎症途径.
主要方法:
- 鼠被分为五组:对照组,单独使用WP,单独使用IR,在IR之前和之后使用WP (WP+IR),以及在IR后使用WP (IR+WP).
- 照射剂量分别在第4天和第6天为6Gy和3Gy.
- 生物化学标记物 (MDA,TAC,SOD,CAT),炎症性细胞因子 (TNF-α,IL-6),基因表达 (NF-κB/p65,NRF2,HO-1),以及组织学分析在辐射后的7天和14天对语言组织进行.
主要成果:
- 紫外线暴露引起了显著的氧化应激,其证据是MDA增加和语言组织中TAC,SOD和CAT水平降低.
- IR导致血清IgE升高,炎症性细胞因子 (TNF-α,IL-6),NF-κB/p65mRNA,以及改变NRF2/HO-1表达,以及组织学损伤.
- 施用WP,特别是在IR前和后给药时,有效地减轻了IR引起的氧化损伤,炎症和组织学变化.
结论:
- 乳清蛋白分离物显示出显著的辐射保护作用,对大鼠的玛辐射诱导的语言损伤.
- WP的保护作用归因于其抗氧化和抗炎性质,可以抵消IR诱导的氧化应激和炎症.
- 对接受放射治疗的癌症患者来说,WP补充可能是一个有益的饮食策略,以减少与治疗相关的副作用.
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