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针对晚期/转移性尿路细胞癌的HER2向治疗的进展

Mengnan Qu¹, Li Zhou¹, Xieqiao Yan¹

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Genitourinary oncology, Peking University Cancer Hospital & Institute, Beijing, China.

Bladder (San Francisco, Calif.)

|December 29, 2023

概括

转移性尿路细胞癌 (mUC) 显示HER2过度表达,但向治疗的成功程度有限. 像RC48-ADC这样的新方法证明了治疗这种具有挑战性的癌症的潜力.

科学领域:

在瘤学瘤学.
尿癌研究尿癌研究
有针对性的癌症治疗.

背景情况:

尿路癌 (UC) 是一种常见的尿路系统恶性瘤,在晚期/转移阶段 (mUC) 预后不佳.
UC表现出人类表皮生长因子受体2 (HER2) 过度表达的高率,类似于乳腺癌.
与乳腺癌不同,UC中的HER2阳性是可变的,具有不一致的蛋白质过度表达和基因放大,使向治疗策略复杂化.

研究的目的:

审查针对mUC的HER2向治疗的进展.
讨论 HER2 在 mUC 发育和进展中的作用.
探索克服抗HER2抗性的策略,并总结新的治疗方法.

主要方法:

在mUC中对HER2向疗法的文献综述.
对HER2向药物的临床试验数据的分析.
讨论耐药机制和新兴的治疗策略.

主要成果:

之前针对HER2的治疗方法 (特拉斯图祖马布,珀图祖马布,拉帕蒂尼布,阿法替尼布,内拉替尼布) 在HER2阳性mUC中基本失败.
由于不良事件,T-DM1的临床试验被停止.
一项II期试验表明RC48-ADC在mUC患者中的有效性.

结论:

尽管HER2过度表达,但传统的抗HER2药物对mUC无效.
像RC48-ADC这样的新兴抗体-药物联合体显示出对mUC治疗的希望.
进一步研究克服抗HER2耐药性和新的治疗策略对于改善mUC结果至关重要.

关键词:

在HER2中,HER2是HER2.先进/转移的膀癌.晚期/转移性尿路细胞癌有针对性的治疗.

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