瘤微环境会影响食道腺癌对治疗的反应
Clemence J Belle1, James M Lonie1, Sandra Brosda1
1Surgical Oncology Group, Frazer Institute, The University of Queensland, Brisbane, QLD, Australia.
Frontiers in immunology
|December 29, 2023
概括
消化管腺癌 (OAC) 治疗不佳,需要新的策略. 用免疫检查点抑制剂向瘤微环境 (TME) 显示出改善患者结果的希望.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 消化管腺癌 (OAC) 呈现治疗反应不佳和低生存率,由免疫抑制的瘤微环境 (TME) 驱动.
- 在OAC TME中的炎症与更好的患者结果相关,突出其临床意义.
- 了解TME的组成对于开发更有效的OAC疗法至关重要.
研究的目的:
- 审查目前对OAC瘤微环境 (TME) 的理解.
- 探索OAC TME内的免疫细胞种群的临床意义.
- 讨论新兴的治疗组合,特别是免疫检查点抑制剂,用于OAC治疗.
主要方法:
- 对OAC,TME,免疫透物和治疗策略研究的文献综述.
- 对支持使用免疫检查点抑制剂的临床试验数据的分析.
- 探索与TME成分相关的生物标志物,以预测治疗反应.
主要成果:
- OAC TME主要是免疫抑制的,有助于治疗耐药性.
- 新辅助化学放射疗法可能会增强免疫透和免疫检查点表达 (例如PD-1/PD-L1,CTLA4,LAG-3,TIGIT,ICOS).
- 虽然免疫检查点抑制剂显示出希望,但可变的结果需要改进生物标志物.
结论:
- 针对OAC TME,特别是使用免疫检查点抑制剂,是治疗进步的关键领域.
- 对TME成分的进一步研究对于识别预测生物标志物和优化治疗策略至关重要.
- 基于TME特征的个性化治疗方法可以提高OAC患者的生存率.
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