血压对认知障碍患者死亡率的影响:一项前性队列研究
YanChang Shang1, ShuHui Wang2, Chao Wei1
1Department of Geriatric Neurology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Frontiers in cardiovascular medicine
|December 29, 2023
概括
认知障碍 (CI) 的老年人面临更高的死亡风险. 高血压显著放大这些风险,特别是在心血管疾病 (CVD) 死亡率方面,这强调了在这个人群中需要血压管理的必要性.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 心血管健康 心血管健康
- 神经学和认知科学 神经学和认知科学
背景情况:
- 认知障碍 (CI) 是老年人死亡的一个重要风险因素.
- 高血压和CI对死亡率的独立和联合影响仍然不完全理解.
- 这项研究涉及高血压与CI老年人死亡率之间的有争议的关系.
研究的目的:
- 研究高血压对全因和心血管疾病 (CVD) 特定死亡率的影响.
- 在被诊断患有认知障碍的老年人中检查这些影响.
- 分析高血压和CI对潜在队列中死亡率结果的协同影响.
主要方法:
- 利用了来自2011-2014年国家健康和营养检查调查 (NHANES) 的2925名参与者 (60岁以上) 的数据.
- 死亡率数据 (所有原因和CVD特定) 通过国家死亡指数链接追踪到2019年12月.
- 使用Kaplan-Meier生存分析和Cox比例危险回归来计算危险比率 (HR).
主要成果:
- 患有CI的参与者具有显著更高的全因 (HR 1.96) 和心血管疾病特异性死亡率 (HR 2.8) 的风险.
- 在CI患者中,高血压进一步增加了全因死亡风险 (HR 2.73) 和心血管疾病特异性死亡风险 (HR 5.3).
- 高血压和CI对死亡率的综合影响在年轻的老年人 (60-69岁) 中更为明显.
结论:
- 认知障碍显著增加死亡风险,特别是当与高血压同时发生时.
- 高血压加剧所有原因和心血管疾病特异性死亡率在CI的老年人中.
- 有效的高血压管理对于减轻认知障碍患者过度死亡风险至关重要.
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