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A Proinflammatory, Degenerative Organ Culture Model to Simulate Early-Stage Intervertebral Disc Disease.
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在脊椎间盘的静态和动态压缩过程中,TRPV4通过差异控制炎症性细胞因子网络

Garrett W D Easson1,2, Alireza Savadipour1,2,3, Christian Gonzalez4

  • 1Department of Orthopaedic Surgery Washington University in St. Louis St. Louis Missouri USA.

JOR spine
|December 29, 2023
PubMed
概括

在机械负荷下,暂时受体潜在化物4 (TRPV4) 通道调节椎间盘 (IVD) 中的炎症性细胞因子产生. TRPV4的激活升高保护性细胞因子的调节,并抑制免疫细胞的招募,保持IVD的恒常性.

关键词:
在 TRPV4 中.退化 退化 退化动态压缩的动态压缩.炎症性细胞因子网络 炎症性细胞因子网络椎间盘之间的椎间盘.静态压缩静态压缩

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