动脉硬和氧化LDL独立与SARS-CoV-2的急性后续发生相关
Sokratis N Zisis1, Jared C Durieux2, Christian Mouchati1
1School of Medicine, Case Western Reserve University, Cleveland, Ohio.
Pathogens & immunity
|December 29, 2023
概括
SARS-CoV-2 (PASC) 后急性后果与动脉硬和氧化LDL (ox-LDL) 相关,特别是在神经和心肺PASC表型中. 对PASC中氧化应激的进一步研究是有必要的.
科学领域:
- 心血管医学 心血管医学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 持续的症状,称为SARS-CoV-2 (PASC) 后急性后续,影响COVID-19幸存者.
- 导致PASC及其多种表型的根本原因尚不清楚.
- 内皮功能障碍是PASC发展的一个潜在因素.
研究的目的:
- 调查内皮功能障碍与COVID-19和PASC的存在之间的关联.
- 探索动脉弹性,氧化LDL (ox-LDL) 和PASC表型之间的关系.
主要方法:
- 分析了379名参与者的潜在队列 (COVID阴性,COVID阳性,有或没有PASC).
- 使用EndoPAT测量了内皮功能 (RHI) 和动脉弹性 (AI).
- 收集了患者数据,包括实验室,代谢测量,炎症标志物和ox-LDL.
主要成果:
- 在COVID-19/PASC和内皮功能 (RHI) 之间没有发现显著的关联.
- 动脉硬与年龄,女性性别和CRP有关.
- 增加的AI和ox-LDL水平独立地与更高的PASC概率有关,特别是在神经/心肺表型中.
结论:
- 在PASC,ox-LDL和动脉硬之间存在独立的关联.
- 神经和心肺PASC表型表现出最显著的动脉弹性损伤.
- 氧化应激需要进一步研究其在PASC病理生理学中的作用.
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