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大脑功能连接模式与前体偏头痛症状相关

Xia Zhe¹, Hailian Zhang², Min Tang³

¹Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Frontiers in neuroscience

|December 29, 2023

概括

静脉偏头痛 (VM) 与大脑连接的改变有关,特别是在默认模式网络和视觉皮层. 这些功能变化与症状严重程度相关,为VM机制提供了洞察力.

科学领域:

神经科学是一个神经科学.
医疗成像医学成像
神经学神经学

背景情况:

功能磁共振成像 (fMRI) 研究表明,前体偏头痛 (VM) 中大脑网络功能发生变化.
VM与大脑功能的潜在变化有关,需要进一步调查.
在VM中理解间接大脑功能对于阐明疾病机制至关重要.

研究的目的:

为了研究VM患者在间歇期期间的静止状态功能连接 (FC) 模式.
结合voxel智能度中心性 (DC) 和基于种子的FC分析,绘制大脑变化图.
为了将大脑功能变化与VM的临床症状相关联.

主要方法:

招募了38名VM患者和33名健康对照.
在各组之间计算和比较中心度 (DC).
进行了基于种子的FC分析,对变化DC的区域进行了分析,并将研究结果与临床指标相关联.

主要成果:

与对照人群相比,VM患者表现出较低的双边中间前额皮层 (mPFC) DC和较高的右叶DC.
脑膜炎患者的双边mPFC与多个大脑区域,包括后带皮层和小脑的FC降低.
损坏的FC和DC值与VM症状严重程度 (疼痛强度,发作频率,头障碍库存得分) 有负相关性.

结论:

研究结果显示,VM患者的默认模式网络和视觉皮层发生了显著的变化.
这些大脑连接的变化为VM的复杂病理生理学提供了更深入的见解.
该研究强调了大脑网络功能障碍与VM中的临床表现之间的关联.

关键词:

默认模式网络模式默认模式网络模式中心性的程度.功能连接性的功能连接性前额叶皮层前额叶皮层.前立腺偏头痛是前立腺偏头痛.

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