患有女性生殖系统恶性瘤的患者胰岛素抵抗的预后值:一个多中心队列研究
Xiao-Yue Liu1,2,3, Qi Zhang1,2,3, Xi Zhang1,2,3
1Departments of Gastrointestinal Surgery and Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Immunity, inflammation and disease
|December 29, 2023
概括
胰岛素抵抗和炎症预测女性生殖系统癌症的预后不佳. 禁食甘油三糖 (TyG) 指数与中性粒细胞-淋巴细胞比率 (NLR) 结合,为患者的结果提供了卓越的预测价值.
科学领域:
- 妇科瘤学 妇科瘤学
- 代谢综合征是代谢综合征的一种.
- 癌症预后 癌症预后
背景情况:
- 胰岛素抵抗 (IR) 和全身炎症在癌症患者中很普遍,通常与不良结果有关.
- 有限的研究已经探索了IR在女性生殖系统恶性瘤的预后影响.
- 这项研究解决了了解IR和炎症在这个特定患者群体中的预测作用的需要.
研究的目的:
- 研究女性生殖系统恶性瘤患者胰岛素抵抗 (IR) 和全身炎症的预后意义.
- 评估各种脂质比率和禁食甘油三糖 (TyG) 指数作为IR的替代品.
- 为了确定IR指标和炎症标志物的综合预后值.
主要方法:
- 一项前性,多中心,现实世界队列研究包括571名患有女性生殖系统恶性瘤的患者.
- 用脂质比率 (LHR,TCHR,TGHR) 和TyG指数来评估胰岛素耐药性.
- 使用卡普兰-梅尔分析和考克斯回归模型来评估整体存活率和危险率.
主要成果:
- 无论是IR还是炎症,都与研究人口的整体存活率有负相关.
- 高水平的LHR,TCHR,TGHR,TyG和中性粒细胞-淋巴细胞比率 (NLR) 与更糟糕的预后有显著关联.
- TyG指数在IR指标中显示出最强的预测值,高TyG和高NLR的组合显示出增强的预测能力 (HR:3.22).
结论:
- 胰岛素耐药性是女性生殖系统恶性瘤预后的独立预测因子,无论使用哪种特定的IR替代品.
- TyG指数和NLR的结合提供了更强大的预测这些癌症诊断的妇女的预后结果.
- 这些发现突显了代谢和炎症标志物的潜在临床实用性,用于治疗患有妇科恶性瘤的患者.
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