鸟类的外胚膜在发育早期对黄皮皮质做出反应
Emily P Harders1, Mitch Agustin1, Ryan T Paitz1
1Illinois State University, School of Biological Sciences, Campus Box 4120, Normal, IL 61790, USA.
Biology open
|December 29, 2023
概括
蛋黄中的母性压力激素,如皮质,可以改变胚胎的发育. 的胚胎外膜通过增加乙-CoA thioesterase 13 (Acot13) 表达来响应皮质,但这种效果是暂时的.
科学领域:
- 发育生物学是发展生物学.
- 内分泌学 在内分泌学.
- 比较生理学比较生理学
背景情况:
- 孕产妇的压力和高血糖皮质激素水平可能会影响后代的发育.
- 在卵性物种中,胚胎外膜会代谢母体在蛋黄中沉积的葡萄皮质.
- 这些膜对葡萄糖皮质激素的反应还不太清楚.
研究的目的:
- 为了调查的胚胎外膜是否对黄皮皮质有反应.
- 为了确定这种反应是否依赖于剂量及其持续时间.
- 评估皮质的代谢物是否会引起类似的反应.
主要方法:
- 在胚胎中量化了乙-CoA硫酶13 (Acot13) 基因表达.
- 将不同剂量的皮质或其代谢物 (5β-皮质) 注入蛋黄中.
- 在不同发育阶段 (4,6,8,10天) 采集了胚胎外膜样本.
主要成果:
- 皮质在第4天显著诱导了Acot13表达,表达增加与更高剂量相关.
- 在第4天和第6天,Acot13表达仍然升高,但在第8天和第10天却没有升高,这表明反应是暂时的.
- 5β-皮质没有影响Acot13的表达,这表明皮质通过代谢被禁用.
结论:
- 的胚胎外膜在早期发育过程中对母体皮质具有暂时的敏感性.
- 这种由Acot13调解的反应发生在关键的发育窗口期间.
- 这些发现表明一种机制,通过该机制,母体衍生的葡萄皮质激素可以影响胚胎发育和潜在的后代表型.
相关概念视频
Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Embryonic Connective Tissues
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Development of the Sexual Organs in the Embryo and Fetus
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...


