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对HER2-阳性乳腺癌免疫组织化学的诊断准确性

Siwaporn Thanasan¹, Kweekrong Sukhakul¹, Sakchai Chitpakdee¹

¹Pathology Department, Rajavithi Hospital, Phayathai Road, Ratchathewi, Bangkok, Thailand.

Asian Pacific journal of cancer prevention : APJCP

|December 29, 2023

概括

仅通过免疫组织化学 (IHC) 可以准确地诊断出人类表皮生长因子受体2 (HER2) 阳性乳腺癌. 这种方法具有很高的准确性,可能简化了接受抗HER2治疗的患者的诊断.

科学领域:

在瘤学瘤学.
病理学病理学病理学
生物标志物诊断生物标志物诊断

背景情况:

目前对HER2阳性乳腺癌的诊断依赖于ASCO/CAP 2018年指导方针,结合局部杂交 (ISH) 和免疫组织化学 (IHC).
IHC是一种具有成本效益和可访问的技术,对于资源有限的环境特别有价值.

研究的目的:

为了验证单独使用IHC对HER2阳性乳腺癌的诊断准确性.
根据当前的指导方针,将IHC结果与双ISH (DISH) 对HER2放大进行比较.

主要方法:

分析了510个乳腺癌组织样本,使用IHC跟随DISH.
专注于58个IHC模两可 (2+) 和98个IHC阳性 (3+) 样本进行详细的诊断价值评估.

主要成果:

IHC表现出高诊断性能,灵敏度为87.96%和特异性为93.75%.
准确率为89.74%,正预测值为96.94%,负预测值为77.59%.

结论:

阳性IHC结果 (得分3+) 显示强烈同意HER2放大.
仅仅IHC可能就足以诊断HER2阳性乳腺癌,这可能消除了在抗HER2治疗决策中需要DISH确认的需要.

关键词:

在HER2中,HER2是HER2.乳腺癌乳腺癌乳腺癌双染色在现场混合化.免疫组织化学免疫组织化学

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